Contact Tracing Apps Were Big Tech’s Best Idea for Fighting COVID-19. Why Haven’t They Helped?

When the Nevada Department of Health and Human Services launched COVID Trace, one of the nation’s first COVID-19 contact-tracing smartphone apps, on Aug. 24, state health authorities “strongly recommended” all 3 million-plus Nevadans download and use the app. But two and a half months later, adoption remained well short of that ambitious goal—the app has been downloaded just under 70,000 times as of Nov. 9, representing just under 3% of the state’s adult population. A total of zero exposures were registered in the app throughout the month of September, during which the state reported more than 10,000 new cases. One of the first positive test results logged into the app was submitted in early October by Nevada’s pandemic response director, who himself had contracted the virus. Nevada is currently reporting roughly 1,200 new COVID-19 cases daily, and the app doesn’t seem to be making a difference.

While researchers have worked for months to develop COVID-19 vaccines and treatments, contact-tracing apps like COVID Trace have been touted as one of the technology world’s most promising contributions to the fight against the pandemic. But seven months into the U.S. outbreak, such apps have made slow progress across the country, hampered by sluggish and uncoordinated development, distrust of technology companies, and inadequate advertising budgets and messaging campaigns.

“People are trying whatever they can think of, and this is one of those things,” says Jeffrey Kahn, a professor of health policy and management at Johns Hopkins University. “Whether it’s worth the investment, it’s really hard to answer that until there’s more information.”

Most U.S. contact-tracing apps are built by state governments, but underpinned by a Bluetooth-based exposure notification protocol released in May by Google and Apple in a rare joint venture. Smartphones running apps using the Google-Apple technology can exchange randomly generated identification numbers with other nearby devices; the apps then alert users if someone they’ve been in contact with later inputs a positive COVID-19 test so they can take appropriate measures, like getting tested. The idea was to augment, not replace, traditional contact tracing—a manual process in which human investigators interview infected individuals, then contact others with whom they recently spent time. (While many states have been ramping up their contact-tracing programs, many of these efforts have been overwhelmed by the sheer amount of viral spread in recent weeks.)

But five months after the Google-Apple project launched, apps using their protocol are available to the general public in only 10 states and Washington, D.C. Even in states that have rolled out contact-tracing apps, adoption generally remains low. Why?

Part of the problem, according to public-health experts, has been a lack of coordination by the federal government, which could have, for example, created a national digital contact-tracing solution and encouraged states to opt in. Absent direction or incentives from Washington, many states have chosen not to launch contact-tracing apps at all. Even states that have launched contact-tracing apps were initially wary of investing their limited resources in an unproven solution. Officials in New York, for example, told TIME they were interested in Google and Apple’s initial pitch as the pandemic battered the Empire State this spring, but first wanted to shore up their traditional contact-tracing program. The state eventually launched an app in early October.

Contact-tracing apps have also been slowed by state health departments’ lack of tech expertise, according to public-health officials and technologists. “From the perspective of an app developer that sat in those contracting queues in places like New York and California, states were utterly unequipped to start making procurement decisions on contact-tracing apps,” says Teddy Gold, executive director of Zero, a non-profit formed this spring to make pandemic response software. “You’d get sent from the public health department to the governor’s office, to the [chief information officer], back to a mayor’s office, back to the chief information security officer’s office. It was this Kafkaesque thing where no one had ever done this. No one had ever developed a contact-tracing app before. States don’t develop apps.” Dr. Norm Oliver, Virginia’s state health commissioner, agrees. “Public-health departments around the country, their strong suit is not going to be app development,” Oliver says.

At first, states using the Google-Apple protocol had to contract with developers on their own to build contact-tracing apps, an expensive and complicated process. In September, with only a handful of state apps online since the protocol’s May launch, the companies released Exposure Notifications Express, a basic, pre-built version that states can use instead of developing their own apps. Users in areas where the service is active can opt in after receiving a push notification, a feature likely to save marketing costs. A Google spokesperson says the company is seeing “momentum” in adoption among states thanks to collaboration with public health authorities and ongoing software improvements. Apple did not respond to TIME’s requests for comment.

Some officials say the technology companies have done the best they can considering the constantly changing pandemic situation and the inherent complexities of public-health administration. “Apple and Google as tech companies, I think they were trying to find where they could best fit in to help, using technology that they knew was available without saying that they’re the public health authority, which they’re not,” says Jeff Stover, an executive advisor at the Virginia Department of Health. But getting a contact-tracing app up and running is still not as simple as flipping a switch, and some technologists and health experts are frustrated over delays in getting these apps into wide use. “We’re 200,000 dead people late,” says Gold. “It’s like the plane has crash-landed and everyone has died and the captain scrambles out of the rubble and he’s like, ‘Okay guys, in an emergency landing there are lifejackets under your seats.’”

Of course, whether an app takes a week or six months to build doesn’t matter if people aren’t downloading and using the resulting software—a problem in most states that have launched contract tracing apps. Alabama’s contact-tracing app, for example, was downloaded only 125,000 times between its release in mid-August and late October, a figure equivalent to just over 3% of the state’s adult population. Wyoming, which launched a contact-tracing app around the same time, has seen fewer than 5,000 downloads as of late October, equivalent to just 1% of the state’s adults. Apps in North Carolina and Pennsylvania had been downloaded by an equivalent of only 3-4% of their adult populations by the end of October, just over a month after launching. In New Jersey and New York, which both launched apps on Oct. 1, an equivalent of around 4% of resident adults signed up for their apps in less than a month.

fg that contact-tracing apps are tracking their location or other personal information. “Concern about privacy is one of the things that’s suppressing adoption,” says Christian Sandvig, director of the Center for Ethics, Society, and Computing at the University of Michigan. That’s despite the fact that the Google-Apple protocol—which doesn’t track or share users’ locations or identities—represents the “gold standard” for privacy protection, Sandvig says. Some health experts have even argued that these apps were built with such an emphasis on privacy that they’re actually less useful in fighting the pandemic, in part because they don’t collect data like the locations where potential infections are taking place.

But many users may not see it that way, especially in an era when Americans’ trust in Big Tech is eroding and technology firms are catching flak from all sides of the political spectrum. In some instances, privacy concerns are even killing contact-tracing apps in the cradle—South Carolina, for instance, announced plans in May to deploy a Google-Apple powered contact-tracing app, only to shelve the plan the next month after lawmakers banned such software over privacy concerns.

In some states, sparse adoption may also be linked to a lack of advertising funding. In the two U.S. states with the highest adoption rates—Delaware (7.3% adoption) and Virginia (10.6% adoption)—officials have spent $0.11 and $0.18 per resident on advertising their apps, respectively. Officials in those states attribute their relative success to aggressive outreach efforts; in Virginia, that included a PSA featuring students from around the state as well as marketing materials in both English and Spanish. But in Wyoming and Nevada, where adoption sits at a paltry 1.1% and 2.9% of resident adults, respectively, advertising funds are scant. Wyoming isn’t spending any money at all to promote its app. The private-sector partners behind Nevada’s COVID Trace, who also paid to build the app in the first place, are spending a small amount on ads—around $0.03 per resident, plus ad inventory contributed by Google and a volunteer effort from Vegas-area performers—while the state is spending none of its own funds. The strategy has so far failed to bear fruit. “I feel like I’ve talked about COVID Trace every day since we launched it, and people will say ‘oh I didn’t know you did an app,’” says Julia Peek, Deputy Administrator of Nevada’s Community Health Services. “It’s like, ‘what are we doing wrong to promote this?’”

While it’s obvious that no U.S. state has achieved anything resembling a satisfactory adoption rate, it remains unclear how many people in a given population need to download and use contact-tracing apps to control viral spread. In May, researchers pegged that figure at 60%—far more than what U.S. states are seeing so far. But newer research from Oxford University and Google says that exposure notification apps could help reduce infections at any level of uptake. “There have been a lot of conversations in the past about [whether] you have to achieve minimum thresholds in terms of adoption levels,” says Larry Breen, chief commercial officer at Nearform, which developed a contact tracing app for Ireland as well as multiple U.S. states. “I’ve never accepted that as the right thing. As soon as you get the digital contact-tracing solution out into any cluster or group of people, it’s providing some level of protection.”

Even the highest adoption rates among U.S. states are far below those in countries like Ireland, where more than a third of the adult population downloaded the government’s contract-tracing app by early October, or Germany, which reached 27% adoption in September (though even both of those results fall well short of mass adoption). Breen says Irish officials and politicians have maintained a unified, consistent message promoting the app, which hasn’t been true in the U.S. “There’s a lot of confusion and different messaging coming out,” he says. Other countries, like Austria, have comparable adoption rates to Virginia.

All told, despite the relative success of states like Delaware and Virginia, agonizingly slow rollouts and uncertain public health benefits over the past few months have caused some experts to doubt the assumption that contact tracing apps can help bring the spiraling U.S. COVID-19 outbreak under control. “There’s an ultimate question here…which is, ‘Is this a great opportunity for software?,'” says Sandvig. “It may be that it is not.”

IIT Delhi set to conduct Covid-19 tests on ICMR-approved campus lab for half the price

IIT Delhi set to conduct Covid-19 tests on ICMR-approved campus lab for half the price The test is being conducted at a new Indian Council of Medical Research-approved laboratory opened on the campus. The lab is using Corosure, a testing kit which uses the diagnostic assay developed by IIT Delhi. The kits are being manufactured by New Tech Medical Devices. https://ift.tt/eA8V8J

FDA Allows Emergency Use of Antibody Drug to Fight COVID-19

(WASHINGTON) — U.S. health officials have allowed emergency use of the first antibody drug to help the immune system fight COVID-19, an experimental approach against the virus that has killed more than 238,000 Americans.

The Food and Drug Administration on Monday cleared the experimental drug from Eli Lilly for people 12 and older with mild or moderate COVID-19 not requiring hospitalization. It’s a one-time treatment given through an IV.

The therapy is still undergoing additional testing to establish its safety and effectiveness. It is similar to a treatment President Donald Trump received after contracting the virus last month.

Early results suggest the drug, called bamlanivimab, may help clear the coronavirus sooner and possibly cut hospitalizations in people with mild to moderate COVID-19. A study of it in hospitalized patients was stopped when independent monitors saw the drug did not seem to be helping in that situation.

The government previously reached an agreement to buy and supply much of the early production of Lilly’s drug.

Only one drug — Gilead Sciences’ remdesivir — has full FDA approval for treating COVID-19. Government treatment guidelines also back using dexamethasone and other steroids for certain severely ill, hospitalized patients.

One other treatment has an emergency use designation now — convalescent plasma, or the blood of COVID-19 survivors. No large studies have shown it to be more effective than usual care alone, however.

The new drug is part of an emerging family of biologic therapies that offer a promising new approach to preventing serious disease and death from COVID-19. Experts say the infused drugs could serve as a therapeutic bridge to help manage the virus until vaccines are widely available.

The drugs are laboratory-made versions of antibodies, blood proteins which the body creates to help target and eliminate foreign infections. The new therapies are concentrated versions of the antibodies that proved most effective against the virus in patient studies.

Regeneron Pharmaceuticals Inc. also has asked for emergency authorization for an antibody drug it is testing, the one Trump received.

FDA regulators authorized the Lilly drug using their emergency powers to quickly speed the availability of experimental drugs and other medical products during public health crises.

In normal times the FDA requires “substantial evidence” to show that a drug is safe and effective, usually through one or more large, rigorously controlled patient studies. But during public health emergencies the agency can lower those standards and require only that an experimental treatment’s potential benefits outweigh its risks.

The emergency authorization functions like a temporary approval for the duration of the COVID-19 pandemic. To win full approval, Lilly will have to submit additional research to fully define the drug’s safety and benefit for patients.

The government has signed an agreement with Lilly to spend $375 million to buy 300,000 vials of the drug. How many doses that would provide is unclear. Each vial contains 700 milligrams and that dose proved ineffective in the early results. It took four times that amount — 2,800 milligrams — to show any effect.

The Lilly drug is authorized for people 12 and older who weigh at least 40 kilograms (about 88 pounds), and who are at high risk for progressing to severe COVID-19 and/or hospitalization. This includes those who are 65 years of age or older, or who have certain chronic medical conditions.

___

AP chief medical writer Marilynn Marchione in Milwaukee contributed to this report.

Your top 10 natural immunity heroes

Image: iStock

Looking for natural ways to stave off the winter sniffles this season? We’ve put together a quick and easy guide to supporting your immune system without ever opening the medicine cabinet. And it involves eating garlic and power-napping – what more could you ask for?

1. Olive Leaf Extract

You know how health gurus are always going on about the Mediterranean diet? Well, it turns out you can bottle its benefit in the form of olive leaf extract. The not-so-secret ingredient is oleuropein – a polyphenol known for being anti-inflammatory and anti-oxidant. Studies have shown it acts effectively against a range of microbes, like the ones that cause certain strains of flu. Comvita are such big fans that they’ve packed 20 times as many polyphenols into their olive leaf extract as you’ll find in extra virgin olive oil. Plus, they’ve decided to double-down on the immune support – well, triple-down, actually – with the addition of zinc and copper.

2. Exercise

If you’re looking for an all-natural way to support your immune system, you can’t do much better than regular exercise. As well as contributing to overall health, which helps your body stay at its peak, exercise can promote circulation, which keeps your immune system’s cells moving. It also prompts your body to react to the physiological stress by sending out your all-important white blood cells, which are at the front line of your body’s natural defences.

3. Vitamin C

There’s a reason your mum always told you to drink orange juice when you got a cold – although it might not be exactly the one you think. While vitamin C hasn’t been shown to prevent you from getting colds in the first place, it has been shown to shorten the amount of time you’re ill for (if taken regularly rather than just once your symptoms start). Fortunately, it’s easy to incorporate into your diet, with plenty of foods such as peppers, strawberries and even potato being rich in Vitamin C.

4. Pineapple Juice

Another Vitamin C-packed food is pineapple juice – and that’s not its only benefit. Pineapple is a rich source of bromelain, which is an enzyme with strong anti-inflammatory properties. It’s often used to help ease coughs, and studies have found that eating pineapple may reduce the likelihood of infections – or at least shorten their duration. It also contains manganese, which is known for its antioxidant properties. And there is, of course, the added benefit of it being delicious.

5. Propolis

Propolis is the bee’s lesser-known production, but it’s jam-packed full of benefits! This compound is used by hives to repair their home and to prevent bacterial, viral and parasitic infections from getting inside. Worker bees make it using the natural resin that trees produce when they’re wounded, combined with beeswax. Known for its cellular and immune support, Propolis is a great way to give your body an extra boost and Comvita have popped it into easy, on-the-go capsules, oral sprays and elixirs.

6. Hand-washing

It might be annoying to have the ‘Happy Birthday’ song permanently stuck in your head, but it’s a small price to pay for the many benefits of hand-washing. Keeping your fingers clean can stop you from spreading bugs to other parts of your body as well as the surfaces you touch and the people you interact with. And, while hand sanitiser can be useful when you’re on the move, the best method is classic soap-and-water, which dislodges viral cells from your hands and can make it easier to cover a greater surface area.

7. Zinc

A nutrient-rich diet is an important part of keeping your body at its best, and zinc is one you’ll want to stay stocked up on. This essential nutrient helps your immune system fight off viruses and bacteria by breaking down their proteins. Zinc also helps with repairing your cells and making proteins. Your body doesn’t make zinc, but you can get plenty of it through your diet by picking foods such as oysters and red meat or, for the plant-based, beans, nuts and whole grains.

8. Garlic

As if you needed an excuse to add extra garlic to your food, it also contains allicin, which is a natural antibiotic. It helps support your body’s natural cells when they’re fighting off viruses, and some studies have suggested that garlic can reduce your risk of developing colds, as well as helping to ease symptoms once you’ve got one. All of which means you should definitely get that extra side of garlic bread with your dinner – heavy on the garlic.

9. Fibre

Fibre is best known for its benefits for your digestive system – but did you know it can help boost your immune system as well? In particular, soluble fibre plays an important role in helping your body recover from infections thanks to its anti-inflammatory properties. Dried beans, oats, rice and potatoes are all high in soluble fibres, are as plenty of greens such as Brussels sprouts and broccoli.

10. Sleep

If all else fails, there’s always a power nap. Getting enough sleep is essential to supporting those all-important T-cells, which are a central part of your immune system. While you’re asleep, your immune system releases cytokines that help to fight off infections – and even more so when your body is under stress. So, if you want an easy way to keep your body fighting fit with no over-the-counter capsules required, try and grab an early night tonight (or a late morning tomorrow, depending on how flexible your boss is…).

Unfortunately, there’s no way to skip over flu season altogether – but good food, a bit of exercise and plenty of rest can help make sure your body is at its best when it does roll around.

For more natural support for your immune system, find the Comvita range in Holland & Barrett stores and online at hollandandbarrett.com

The post Your top 10 natural immunity heroes appeared first on Healthy Magazine | Food | Fitness | Beauty | Health.

Diet and lifestyle during pregnancy linked to modifications in infants’ DNA: A new study has shown pregnant women with obesity could reduce the health risks for their infants through improved diet and more physical activity

Diet and lifestyle during pregnancy linked to modifications in infants’ DNA: A new study has shown pregnant women with obesity could reduce the health risks for their infants through improved diet and more physical activity submitted by /u/mubukugrappa
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Calories by the clock? Squeezing most of your calories in early doesn’t impact weight loss

Calories by the clock? Squeezing most of your calories in early doesn’t impact weight loss submitted by /u/mubukugrappa
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Mothers’ lifestyle predicts when offspring will have first heart attack or stroke: Offspring of mothers with heart healthy lifestyles live nearly a decade longer without cardiovascular disease than those whose mothers have unhealthy lifestyles, new study finds

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