Model Shows How COVID-19 Could Lead to Runaway Inflammation

Model Shows How COVID-19 Could Lead to Runaway Inflammation
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Rogue Antibodies and Gene Mutations Explain Some Cases of Severe COVID-19

Rogue Antibodies and Gene Mutations Explain Some Cases of Severe COVID-19
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https://ift.tt/33BEWrH October 06, 2020 at 11:48PM https://ift.tt/1R552o9

We Still Don’t Know When President Trump Last Tested Negative for COVID-19. Here’s Why That’s a Big Deal

It’s been only about four days since the world learned U.S. President Donald Trump tested positive for COVID-19—but that doesn’t necessarily mean it’s been four days since he was infected.

White House officials and Trump’s personal physician Sean Conley have repeatedly dodged questions about when the President last tested negative for COVID-19. “I don’t want to go backwards,” Conley said when asked about Trump’s last negative test during a Monday press briefing, at which he announced Trump would be discharged from Walter Reed National Military Medical Center to return to the White House.

But the question isn’t only important retroactively. “It matters for a couple of reasons,” says Dr. Megan Ranney, a professor of emergency medicine at Brown University. “The first is because it helps to predict the course of illness. The second reason it matters immensely is because of contact tracing.”

That is, without knowing when Trump last tested negative, it’s impossible to say how many people came into contact with him when he was contagious and may now be unknowingly spreading the virus. Knowing the date of Trump’s last negative test is not going backward; it is crucial to preventing future spread.

The timeline of Trump’s illness has been unclear. He tweeted early Friday morning that he tested positive for COVID-19, shortly after his adviser Hope Hicks tested did. (Wall Street Journal reporting suggests the White House did not disclose a positive test result Trump received on Thursday while waiting for a second test to confirm the results.) On Friday, he received supplemental oxygen and was admitted to Walter Reed before being discharged Monday.

But at a briefing on Saturday, Conley said Trump was 72 hours into his diagnosis—suggesting he was diagnosed with COVID-19 on Wednesday, not Thursday. He later claimed he misspoke and said the President tested positive on Thursday.

If that’s true, the course of Trump’s illness has been unusual, says Dr. Leana Wen, a professor of health policy and management at George Washington University’s Milken School of Public Health and Baltimore’s former public health commissioner.

It typically takes around a week for symptoms to progress to a point where a patient needs oxygen support. If Trump has been tested every day, as is White House protocol, Wen says it’s strange he would go from a negative test on Wednesday to hospitalization on Friday.

“How is it possible that on Wednesday he didn’t have enough of a viral load to pick it up…and by Friday he has low oxygen and needed to be hospitalized?” Wen says. “If that’s the case, there is something worrisome about President Trump’s health.” (Ranney agrees this progression would be unusual, but says “it is not impossible.”)

It’s important to know how far along Trump is in his illness for multiple reasons. First, many patients get worse around day seven to 10. If Trump isn’t there yet, he’s still not out of the woods. The fact that two drugs the President is taking—the antiviral remdesivir and the steroid dexamethasone—are typically reserved for hospitalized patients with advanced COVID-19 only adds to Wen’s concerns, she says.

Second, the U.S. Centers for Disease Control and Prevention recommends patients isolate for 10 days after their symptoms appear to avoid spreading the virus to other people. If Trump only began experiencing symptoms on Thursday, he still may be contagious and should remain isolated back at the White House, as he reportedly plans to do.

Finally, knowing when Trump last tested negative could offer clues about who came into contact with the President when he was potentially contagious, knowingly or not. Studies have shown that people can spread the virus days before they show symptoms, and Trump attended numerous events—including the first presidential debate—during the window when he was possibly contagious.

“It’s possible there are people who were exposed to the President who don’t know it and are actively passing it on to others,” Wen says. Knowing when Trump last tested negative is crucial to running an effective contact tracing effort—an effort that the White House apparently has not yet begun.

For every day of inadequate information, it gets harder to contact trace effectively, says Joseph Eisenberg, chair of the epidemiology department at the University of Michigan’s School of Public Health. Under the best of circumstances, contact tracing is a time- and labor-intensive process. And with each day that passes, more people potentially get exposed to the virus.

“It is concerning from a public-health perspective that that information isn’t out there, from a transparency perspective, from a trust perspective and for the public to know,” Eisenberg says.

Ranney adds that by not disclosing information that could help direct contact tracing, Trump is essentially flouting the public-health guidelines developed by his own administration. The CDC recommends that anyone who has come into contact with a sick person quarantine at home for two weeks, which people can’t do if they don’t know they’ve been exposed.

“If we are to have any hope of controlling the virus in our country, reopening the economy, and getting our kids back to school, it is so essential [that we follow public health procedures],” Ranney says. “When our own President doesn’t follow them, it makes it that much more difficult.”

How to Foster Healthy Body Image in Children

body image kidsI belong to a ladies’ trail running community online. These women are cool, badass humans who perform amazing feats with their bodies. Last month, someone asked the group if they ever struggle with body image. The responses were overwhelmingly affirmative. Hundreds upon hundreds of women responded, “Yes! Me. Every single day.” Only a very few said no.

It was eye-opening and also woefully unsurprising. Most adults I know struggle with body image on some level.

Those of us who are parents would love to spare our children from this emotional baggage, but how do we help our kids develop healthy body image in today’s world? We’re up against massive biological and, especially, social forces. Humans are hardwired to see — and judge — faces and bodies, looking for signs of friendliness, similarity, and fertility. Our early survival as a species depended on it.

The modern diet and beauty industries have taken these natural propensities and exploited them to the nth degree. They bombard us with messaging, both subtle and overt, telling us we must do everything in our power to be as physically attractive as possible. No amount of time or money is too much to invest in the quest for beauty and the “perfect” physique. Oh, and definitely don’t show any signs of aging. The wrinkles, gray hair, and natural softening of the body that comes with growing older? Not allowed! Obviously, if you fail to live up to the ever-changing ideal, it is 100 percent your fault.

Short of moving to the woods and disconnecting from society entirely, we can’t keep our kids from being exposed. Our best hope is to help them develop a healthy body image early. Give them a strong foundation so when they inevitably get caught up in Hurricane Diet Culture, they may waver, but they’ll stay standing.

The strategy is two-fold: First, do your best not to repeat and perpetuate the culture that creates insecurity and negative body image. Second, teach kids to trust, respect, and appreciate their bodies regardless of appearance.


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What is a Healthy Body Image, Anyway?

If you had asked me this a couple years ago, I would have said it’s feeling attractive in your own skin. You should love your body and feel confident no matter what you look like because all bodies are beautiful.

My thinking has changed, though. Now I think a healthy body image means seeing your body as worthy of care and respect — especially self-care and self-respect — period. Instead of focusing on self-love and feeling attractive, I hope my children respect their bodies, want to be good stewards of their health, and anchor their self-worth and self-esteem in factors other than physical appearance.

This isn’t the definitive definition of healthy body image. It’s what we strive for in our family. I don’t pretend that society doesn’t care about appearance, nor tell them that they shouldn’t care either. That would be impossible. Rather, I want them to know that their appearance is only one of many of their qualities, by far not the most interesting or important one, and certainly not the one that determines their value as a person.

9 Ways to Support Healthy Body Image in Kids

I’ll tell you up front: you probably do some of these things “wrong” right now. That’s natural. As parents, we try to bolster our children’s self-esteem. As Primal enthusiasts, we want to teach them about nutrition and building healthy bodies. Our natural inclinations will sometimes lead us afoul of the recommendations below, which come from childhood body image and eating disorder experts.

1. Cut The Negative Body Talk

Negative body talk is when you disparage your own or someone else’s body. It should go without saying that if you want your child to have a healthy body image, don’t criticize their body. That’s the bare minimum. You also have to watch how you talk about other people’s bodies, including your own.

Kids are always listening and internalizing. Negative body talk communicates to them explicitly or implicitly that some bodies are better. They naturally start to see themselves as objects of judgment and wonder whether their bodies are good enough.

“Ugh, I look so gross today.”
“Wow, that person should really avoid spandex, yikes.”
“That skirt is cute, but I can’t wear it with these thighs.”
“I have to put on makeup before this Zoom so I look presentable. Nobody wants to see these eye bags.”

Negative body talk usually comes from a place of insecurity and judgment. It’s also extremely common. Women especially learn that this is a safe way to communicate with female friends.” No dessert for me. I feel so fat today.” “You?! You look amazing. Look at me!” Once you start to tune into it, you realize just how pervasive it is.

Before commenting on your own or someone else’s body, ask yourself: “What is the underlying message I’m sending my kid with this statement? Could it cause them to feel insecure about their own body?” If yes, keep it to yourself.

2. Compliment Your Child on Features Other Than Appearance

Compliments like, “You’re so cute!” or “Don’t you look beautiful in that dress?” are undoubtedly well-meaning. The problem is, they also reinforce to kids that when they are pretty or handsome, that pleases the adults in their life. Being pretty must be important. If they aren’t pretty or handsome, is that displeasing then?

Of course we think our kids are adorable, but kids don’t need to know they are cute. They need to know they are valued and loved. Try these instead:

“Thank you for singing me that silly song. It made my heart happy!”
“You’ve been working so hard on your guitar lessons. You’re really dedicated, that’s awesome.”
“I love how sparkly your dress is! I can’t wait for you to come home and tell me all about the dance.”

This also applies when you’re talking about other people. Instead of, “Your friend Lily is so pretty,” go with “I love to listen to Lily laugh,” or “Lily is such a kind friend.”

3. Focus on What Their Body Does Rather than What It Looks Like

Bodies are made for function, not for decoration. Not all bodies have the same abilities or chronic health issues, of course, but every body is still miraculous. The fact that synapses fire and hearts beat is amazing. Our bodies are basically sacks of meat and fluid that allow us to move through time and space — wild!

Help your child celebrate the wondrous things their body does that have nothing to do with how it looks. “I can tell that your soccer drills are helping you dribble with more precision.” “Isn’t climbing trees fun? You pulled yourself up so quickly!”

4. Speak Respectfully about Your Own Body

Your body is every bit as wondrous as your child’s, but what do they hear you say about it? Most of us rarely speak positively about our bodies, lest we seem conceited. More to the point, we may find it difficult to find nice things to say about ourselves. It’s bad for our children’s body image, and it’s bad for ours.

Kids need to see that it’s ok to talk kindly about their bodies. Just as importantly, it’s possible to be neutral and not judge at all. “Flaws” are just features that don’t have to carry a bunch of emotional weight. If your kids are like mine, they will give you plenty of openings to model speaking respectfully about your body.

“Why is your tummy squishy?” “Tummies come in lots of shapes. This is mine.”
“What are those scars on your legs?” “Those are stretch marks from when my body grew when I was growing you inside me. I like that they remind me of that special time.”
“Your arms are flabby.” “I think my arms are perfect for hugging, thank you very much.”

You can also turn their comments around and ask questions like, “What do you like to do best with your arms?”

5. Banish Diet and Weight-Loss Talk

Your kids will get plenty of exposure to weight-loss and diet culture outside the home. They don’t need to know if you’re trying to lose weight. It’s a slippery slope into making them self-conscious about their own bodies.

The corollary to this is you should avoid labeling some foods as “fattening” or even as “bad.” In fact, avoid attaching good/bad labels to food altogether. This can be especially tricky for us Primal folks who have specific beliefs about what constitutes a healthy way of eating. Lead by example with your food choices. When they inevitably ask why you don’t eat bread or whatever, focus on the pros of the foods you do choose rather than demonizing the foods you avoid. 

You can say things like, “Bread isn’t working for me right now. I feel like I have the energy to do more fun things when I have lots colorful vegetables instead!”

You don’t have to pretend all foods are equally nutritious, nor let food be a free-for-all in your house. The goal is to avoid moralizing and creating shame or guilt around food choices. Young kids won’t understand the concept of protein, fats, and carbs, but you can encourage them to eat a rainbow of foods to get lots of different building blocks. With older kids, gently introduce the concept that some foods can help them feel better and have more energy without condemning “junk foods.”

6. Celebrate Body Diversity

If everybody ate the same foods and did the same exercises, our bodies would still look different. Some people are tall, short, thin, fat, lean, muscly, blond, brunette. Children will always notice these differences, of course, so teach them to notice without judgment. Human diversity is a part of the awe-inspiring diversity of nature.

As they grow, your child will start to realize that their bodies are different from their friends’. Help them appreciate that, even — especially — when they are feeling insecure. “Yes, Max is taller than you, that’s true. I wonder how tall you’ll both be as adults. It’s interesting how some people are tall, while others are short. Everyone gets to see the world a little differently!”

7. Encourage Them to Move for Pleasure

The purpose of exercise needn’t be losing weight, burning calories, “earning” food, or punishing ourselves for something we already ate. Workouts build muscles, speed, or agility. Play engages body and mind, relieves stress, and offers fun and pleasure. Movement of all types feels good and provides energy. That’s why we should be moving our bodies as much as possible. Sometimes even we grown-ups forget that.

Some kids are naturally more active than others. If you have a kiddo who’d happily sit and read for 14 hours while their sibling plays in the pool, don’t make it a battle of wills. Lead by example, modeling everyday movement. Plan active family outings. Better yet, ask them to help you plan activities that they’ll enjoy and which the whole family can do together.

8. Instill Body Trust and Autonomy

In order for your kids to have a healthy body image, they have to feel connected to their bodies. You can support this by teaching them to trust and respond to their bodies’ signals, and by allowing them, within reason, to make choices about their bodies.

This one’s hard because you have to cede some control to your kids: letting them eat when you think they should be full, skip a meal when they should be hungry, don shorts on a cold day, wear a shirt that is two sizes too small, or get a haircut that you think is truly wretched. Sometimes it may even mean letting them choose foods for themselves that you usually avoid.

Think of it as short term pain for long term gain on your part. It might irk the bejeezus out of you when they eat nothing but cheese for lunch for a week, but who’s it hurting really? Nobody who isn’t lactose intolerant.

9. Teach Media Literacy

How great would it be if we could wipe out all body insecurity by simply teaching kids that the images they see in the media are the work of glam squads, body shapers, and lots of photoshopping? Alas, it’s not that simple, but it’s still an important lesson as kids get older.

As they start to notice all the ads for weight-loss programs and laser resculpting, discuss how advertising exploits our insecurities to get us to spend money. Let them be offended by it. Good, maybe they won’t be so easily manipulated.

Guide them in limiting their exposure to media and accounts that make them feel “less than.” Talk to them about what they see and how it makes them feel.

Parenting from a Place of Love and Support Rather than Fear

Years ago, Mark wrote a post about the delicacy of talking to kids about weight. One commenter shared that the best thing their parents could have done would have been to talk to her about weight and health from a place of love instead of judgment and projecting their own fear.

Fear is understandable. We know that this world is not kind to fat people. Fat children commonly experience bullying.1 Fat adults experience street harassment and job discrimination.2 Weight stigma, including at the hands of medical professionals, leads to worse health outcomes for both kids and adults, which then gets attributed to the weight itself.3 4 5

Of course we want our children to grow up healthy and happy, liked by their peers, and accepted by society. We’ll jump at the chance to help them avoid pain whenever possible. Parents who operate from a place of fear usually try to fit their kids to the cultural ideal, which is just as unrealistic for most kids as it is for adults. The better, more sustainable option is to operate from a place of love and acceptance, helping your kid feel good in their current body.

What if I am Really Concerned About My Child’s Health?

If you are genuinely concerned that your child is developing unhealthy habits, please seek out expert guidance from childhood nutrition and movement experts who are also versed in childhood eating disorders. A lot of eating disorders start in childhood when well-intentioned parents put their kids on diet and exercise programs in the name of health.

Body Image is Always a Work in Progress

Prepare yourself for many bumps in the road. As kids grow and their bodies change, they will come up against new challenges. Their peers’ bodies will change at different rates and in different ways than theirs. Even if you try to innoculate them early, they will confront unreasonable beauty standards and diet talk as they engage more with media and as their friends do the same.

You’ll be working on “body stuff” for as long as you parent. Keeping the lines of communication open is one of the best ways to help your kid navigate their way through tricky body image issues. Let them know they can come to you with their insecurities and fears, confident that you will listen without judgment.

Give Yourself the Same Gift of Working on a Healthy Body Image

No parent looks down at their precious newborn and thinks, “I can’t wait to pass all my hang-ups and insecurities on to you.” Somehow, we believe we can instill a healthy body image in our kids, then turn around and hate on our own bodies. That’s some magical thinking right there.

You have to walk the talk. Do you trust your body’s signals and allow yourself to respond with food, rest, or movement as needed? Do you move for pleasure or punishment? Do you speak to yourself with kind words or harsh criticism?

Put on your own oxygen mask before helping someone else, right?

The post How to Foster Healthy Body Image in Children appeared first on Mark's Daily Apple.

As family well-being declines, so does children’s behavior

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The COVID-19 pandemic is bad not only for our physical health, but our mental health as well. It has killed thousands of people and disrupted our lives in terrible ways. So it’s not surprising that a recent survey finds that parents in the US are having a hard time.

Researchers did a national survey in June of 2020 of more than 1,000 parents with children under the age of 18, asking questions about mental health, insurance coverage, food security, child care, and use of health care. They found that compared to before March of 2020,

  • 27% reported worsening mental health for themselves
  • 17% reported worsening behavioral health for their children
  • Moderate to severe food insecurity rose by a third, going from 6% to 8%
  • Employee-sponsored health care went down only slightly, from 63% to 60%
  • 24% reported loss of child care; however, among families with children 5 or younger, it was closer to 50%. Among those who lost childcare, the majority (74%) reported that a parent was watching the child instead. Obviously, this has implications for that parent’s ability to work.
  • 40% reported cancellations or delays in their child’s health care, most commonly well-child care but also specialty and behavioral health care.

Connections to mental and behavioral health

One in 10 families reported worsening mental health for themselves as well as worsening behavioral health for their children. Among those who reported that both were happening, 48% reported loss of regular child care, 16% reported a change in health insurance status, and 11% had worsening food security. Clearly, these families have been hard-hit by the economic effects of the pandemic.

Interestingly, rates of mental health problems were similar across parents of different races and incomes. However, two groups of parents had worse declines in their mental health: female and unmarried parents; and families with younger children.

This survey was done before parents had to manage the implications of a new school year, which is going to bring new stress, especially as it appears that many if not most school systems will be providing at least some of their instruction remotely. Parents again are going to have to juggle working with not just caring for their child, but being sure that they are doing — and understanding — their remote schoolwork. For many families, this is essentially impossible.

It’s also important to remember that compared to families without children, families with children are more likely to be poor — and with job losses continuing and a predicted epidemic of evictions, poor families are going to have even bigger difficulties with basic needs such as food and housing.

The implications of this are staggering. It’s not just short-term homelessness and hunger we have to worry about — it’s the long-term educational, psychological, and health effects on children. This pandemic could quite literally change the course of millions of lives for the worse.

Responding to growing needs

So what can we do? Clearly, as a country we need to devote real financial resources to helping families with children, especially single-parent families and families with young children. That’s the biggest and most immediate need, and will require action from not just government but every possible source of funding.

We also need to devote resources to mental health support, making sure that anyone who needs it can get it. This won’t be cheap either, but the cost will be higher in so many ways if we don’t.

We need to find ways to look out for each other. At this moment when we need to be physically distant to prevent spread of the virus, we also need to be connected. We need to find safe ways to check in with members of our communities. That might be regular phone calls or socially distant check-ins with at-risk families, contributing to food pantries and clothing drives, volunteering to do online tutoring, donating to organizations that are helping families, and anything else that can make a difference.

Part of looking out for each other is doing everything we can to stop the spread of the virus. Along with lots of hand washing, that means that everyone over the age of 2 should wear a mask when they can’t physically distance — and that we must take physical distancing truly seriously. If we let our guard — or our mask — down, we will prolong the pandemic, with everything that means.

We need each other, more than ever.

Follow me on Twitter @drClaire

The post As family well-being declines, so does children’s behavior appeared first on Harvard Health Blog.

How to cope when a loved one is depressed, suicidal, or manic

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If you aren’t sure how to cope when a loved one is depressed, suicidal, or manic, it may be time to learn.

The number of people reporting depression symptoms shot up when the pandemic began, with a recent study suggesting depression tripled among Americans this past spring. The greater burden fell on people with fewer resources, socially and economically, and more exposure to stressful situations, such as job loss. Ongoing surveys are finding that 25% of respondents still report feeling depressed every day.

These kinds of struggles are heart-wrenching to witness. The following suggestions can help you both.

Ways to help care for a loved one in distress

  • Encourage your loved one to get treatment and stick with it. Ask if you can help arrange an in-person or telehealth appointment with a therapist. Gently remind your loved one about taking medication or keeping therapy appointments.
  • Don’t ignore comments about suicide. If you believe your loved one is suicidal, call the person’s doctor or therapist. Mental health professionals can’t divulge patient information without permission, but it is not a violation of confidentiality for the professional to listen to you. In urgent situations, bring your loved one to a local ER or call a local or national crisis hotline for advice. You can also try a suicide prevention text hotline. For example, you can contact the hotline provided by the National Alliance on Mental Illness by texting “NAMI” to 741741.
  • Offer emotional support. Your patience and love can make a huge difference. Ask questions and listen carefully to the answers. Try not to brush off or judge the other person’s feelings, but do offer hope. Suggest activities that you can do together, and keep in mind that it takes time to get better. Don’t worry if you don’t know what to say — it takes a great deal of training (such as that received by therapists) to advise people in emotional distress.
  • Recognize that depression may manifest as irritability or anger, which is often directed toward family and other loved ones. Remind yourself that a disease is causing your loved one to act differently. Try not to blame the person who is struggling — after all, you wouldn’t place blame if a physical illness was causing the person to change.
  • If a loved one has bipolar disorder, try to prevent reckless acts during manic episodes. It’s common for a person to make poor decisions when manic, so it’s a good idea to try to prevent this problem by limiting access to cars, credit cards, and bank accounts. Watch for signs that a manic episode is emerging. Disruption of sleep patterns can trigger an episode, so support your loved one in keeping a regular sleep schedule. Consistent patterns for other activities such as eating, exercising, and socializing may also help.

Take good care of yourself

Finally, remember to pay attention to your own well-being. Consider therapy for yourself, or join a support group. This is a crucial step to lessen your own risk for depression, because caregivers have high rates of depression and anxiety. Other forms of self-care can be very helpful, too.

Numerous mental health organizations sponsor such groups and can also provide you with information on the illness, the latest treatments, and coping tips. With encouragement, knowledge, and support, you’ll feel stronger and more empowered to help shepherd your loved one through this difficult illness.

The post How to cope when a loved one is depressed, suicidal, or manic appeared first on Harvard Health Blog.

Air pollution particles in young brains linked to Alzheimer's damage

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source https://www.reddit.com/r/Health/comments/j66ivw/air_pollution_particles_in_young_brains_linked_to/