The COVID-19 Pandemic Has Erased Decades of Progress on Childhood Vaccination

While the world waits for a COVID-19 vaccine, children across the globe are going without shots already known to be life-saving.

With the world in disarray due to the COVID-19 pandemic, the number of children vaccinated this year against infections like diphtheria, tetanus, pertussis, measles and pneumococcal disease has fallen to levels not seen since the 1990s, according to a new report from the Bill and Melinda Gates Foundation.

“In other words,” the report reads, “we’ve been set back about 25 years in about 25 weeks.”

That stark figure comes from the Gates Foundation’s annual Goalkeepers report, which evaluates global progress on the United Nations’ sustainable development goals, a set of global health, equity and sustainability benchmarks the group hopes to hit by 2030.

Progress on nearly all of the goals has stalled or reversed this year as the world struggles to contain the pandemic. Rates of poverty, malnutrition and childhood mortality are going up for the first time in years. A continued drop in global smoking rates is some of the only good news in the report.

But the significant decrease in childhood vaccinations is among the most dramatic of the report’s findings. International survey data from the Institute for Health Metrics and Evaluation shows that scores of children around the world missed vaccination appointments this spring, compared to last. Last year, 84% of the world’s children received all the vaccines recommended by the World Health Organization. Now, it’s around 70%.

“In some cases, these vaccinations are simply delayed, and kids can ‘catch up’ later without much consequence,” the Gates Foundation’s report reads. “However, some infections, such as measles, spread easily, and even short-term disruptions can lead to immediate increases in illness and death.”

It’s also not clear when children in some parts of the world will be able to catch up. In many developing areas, primary care clinics have closed and nearly all health resources have gone toward combating COVID-19.

Even in developed countries like the U.S., data show that people have skipped preventive and primary care visits in huge numbers. That began this spring, when doctors urged people to push off non-urgent appointments to avoid possible exposure to COVID-19 and conserve resources for physicians treating coronavirus patients. Compared to a normal year, about 2.5 million fewer doses of non-influenza pediatric vaccines were ordered this March and April, according to U.S. Centers for Disease Control and Prevention data.

Central Europe Largely Avoided the First Coronavirus Wave. Why Are Cases Spiking Now?

Central Europe in the past week has seen a spike in daily confirmed coronavirus cases, a major setback for a region that largely avoided the first wave of the virus in the spring. The Czech Republic, an E.U. member state of 10.7 million, registered a country record of 1,382 new infections on Sep. 11, bringing the country’s total cases to over 32,400. In the last week, nearby countries Hungary, Slovakia and Slovenia have also recorded their highest daily caseloads since the pandemic began.

Infections in the Czech Republic previously peaked at around 3 cases per capita (per 100,000 residents) in late March but reached 11.6 cases per capita on Sep. 13. By comparison, the U.S. had 12 cases per capita. Now, the Czech Republic has one of the highest 14-day infection rates in Europe, according to the European Centre for Disease Prevention and Control. Czech Health Minister Adam Vojtech said on Sep. 13 “nobody expected” such a spike in the country.

Governments of central European countries, keen to not impose national lockdowns and prevent further damage to their shrinking economies, have reimposed travel restrictions and renewed social distancing measures for citizens.

The coronavirus pandemic has dealt a major blow to the European economy, particularly countries that rely on tourism. The E.U. economy will decline by an average 8.3% this year, the European Commission said in July. The 27-member bloc, formed after World War II, is expected to fall into the deepest recession in its history. The economies of the Czech Republic and Hungary are predicted to drop by 7.8% and 7% respectively, compared to last year.

Where are cases rising in Central Europe?

The sharpest rise has been recorded in Czech Republic but other countries nearby, including Hungary, Slovakia and Slovenia, are also seeing worrying increases in daily case numbers.

Czech Republic cases

Hungary on Sep. 12 saw its largest daily reported infections since the pandemic began with 916 people testing positive, bringing the country’s total number of infections to 11,825, according to Johns Hopkins University (JHU). Most infections have been registered in the capital city of Budapest.

Slovakia registered a record number of daily cases on Sep. 5 when 226 people tested positive for the virus, according to JHU. Slovenia recorded its highest ever daily caseload with 108 new infections on Sep. 11.

 

Slovakia cases
Slovenia cases

How did Central Europe fare during the beginning of the pandemic?

Central Europe avoided the full brunt of the first wave of coronavirus infections during the spring. On April 15, the U.K. had 159 cases per capita while the Czech Republic had 58 and Hungary, 16.

Luck and foresight initially helped Central Europe to shield itself from the virus, experts say. Some countries in Europe benefited from less international visitors and from going into lockdown when their transmission rates were relatively low. “Central Europe was protected by not being as well connected as international travel hubs and by heeding the warnings from other countries,” says Jennifer Beam Dowd, associate professor of demography and population health at Oxford University.

Why are infections rising in the region?

The spike is likely connected to increased travel combined with a relaxation in restrictions, experts say.

In mid-May, most of Europe began reopening its bars, restaurants and nightclubs, subject to social distancing measures. By mid-June, most of the continent welcomed back travelers from the E.U. and other countries with a stable or decreasing trend of new cases.

The Czech government reopened bars, restaurants and hotels, and allowed gatherings of up to 300 people on May 25 as new daily cases that month were below 111. Hungary reopened all shops and the outdoor sections of cafes and restaurants on May 18 when new daily infections remained under 90. By June 22, the Czech Republic and Hungary had opened their borders to visitors from the E.U. and other countries when new daily infections were below 83 and 29 respectively that month. But in late August the number of daily reported cases in these countries, as well as in Slovakia and Slovenia, began to rise.

Europe as a whole opened up too quickly, says Martin McKee, a professor of European public health at the London School of Hygiene and Tropical Medicine. “There was a great deal of optimism when cases were coming down. But we were only containing it with severe restrictions. As soon as you open up the people, you open up the virus to spread,” he says.

APTOPIX Virus Outbreak Czech Republic
Petr David Josek —AP Photo/Getty ImagesResidents sit to dine on a 500 meter long table set on the medieval Charles Bridge, after restrictions were eased following the coronavirus pandemic in Prague, Czech Republic, Tuesday, June 30, 2020.

Opening up indoor, poorly ventilated spaces has been particularly dangerous. “Large gatherings, crowds in indoor and even outdoor spaces have undoubtedly contributed to the rise we’re now seeing, says Dowd. “It has a ripple effect that appears later on.”

Experts have linked local outbreaks across Europe to the opening of bars and nightclubs in the Czech Republic, France and Switzerland, among others. At the end of July, at least 98 people tested positive following an outbreak in a nightclub in the Czech capital, Prague.

What are countries doing to prevent the spread of the virus?

The Czech government reintroduced mandatory mask-wearing in taxis, public transport, shops and malls, starting Sep. 10 when daily new cases topped 1,000 for the first time. Officials also ordered bars and restaurants to shut between 12 p.m. and 6 a.m., but stopped short of bringing back other measures that could hurt businesses such as closing restaurants and non-essential stores.

Hungary’s nationalist Prime Minister Viktor Orban, who has blamed migrants and foreigners for the spread of the virus, reintroduced an entry ban on all foreigners with some exceptions. The ban went into place on Sep. 1, as the country began to see an uptick in daily cases.

In a Sep. 12 interview with a public broadcaster, M1, Orban said he is drafting a “war plan” to prevent a second wave. “We do not want to introduce a curfew; we do not want movement restrictions,” Orban said. “We want everything to happen as it normally should.” He added that measures to protect the economy and stimulate growth would be introduced in the coming weeks. In the second quarter of the year, Hungary’s GDP fell 13.6% compared to last year (the average decline among E.U. members was 14.4%).

But experts say that prioritizing economic considerations over public health can backfire. “It’s false to frame the introduction of new restrictions as a trade off between health and the economy. If you don’t get the rates down, you can open up the shops but people won’t go into them,” says McKee.

Europe can continue to expect to see a rise in infection transmission in the autumn and winter as people return indoors, experts say, but the level of cases, hospitalizations and deaths are unlikely to reach those seen in the spring peak.

“We’re in a much better place but we need to prepare for a difficult autumn and winter,” says Dowd.

FDA scolds Mylan for 'repeated' manufacturing problems

FDA scolds Mylan for 'repeated' manufacturing problems submitted by /u/MountainsMan55
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FDA scolds Mylan for 'repeated' manufacturing problems

FDA scolds Mylan for 'repeated' manufacturing problems
FDA scolds Mylan for 'repeated' manufacturing problems submitted by /u/MountainsMan55
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FDA scolds Mylan for 'repeated' manufacturing problems

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Mumbai : Now, Covid test at city airport, result in 8 hrs Passengers on all flights landing at Mumbai airport can now undergo an express Covid-19 RT-PCR test at the airport itself, said Mumbai International Airport Ltd on Monday. https://ift.tt/eA8V8J

Researchers demonstrated that x-ray holographic nano-tomography (XNH), a new x-ray microscopy technique, can be used to image relatively large volumes of mouse brain and fruit fly nervous tissue at high resolutions: Could help accelerate efforts to map neural circuits and finally the brain itself

Researchers demonstrated that x-ray holographic nano-tomography (XNH), a new x-ray microscopy technique, can be used to image relatively large volumes of mouse brain and fruit fly nervous tissue at high resolutions: Could help accelerate efforts to map neural circuits and finally the brain itself
Researchers demonstrated that x-ray holographic nano-tomography (XNH), a new x-ray microscopy technique, can be used to image relatively large volumes of mouse brain and fruit fly nervous tissue at high resolutions: Could help accelerate efforts to map neural circuits and finally the brain itself submitted by /u/mubukugrappa
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